Agenda

*Schedule is tentative and is subject to change.

Cellular Therapies and Novel Blood Products in Trauma and Critical Care – The Future of Transfusion Medicine

Wednesday, December 11

11:00 am - 5:00 pm
Registration Open – Aragon Pre-Function North

Badge and Materials Pickup

2:55 pm - 3:00 pm
Welcome & Introductions
  • Moderator: Shibani Pati MD, PhD

    CTTACC Conference Chair
    Associate Professor and Scientific Director of Cellular Therapies UCSF

3:00 pm - 4:00 pm
Session 1 | Sustainability of Research and Successful Translation of Novel Therapeutics in Trauma and Critical Care: from Bench to Bedside and Beyond

Discussion will focus upon funding support for the translational pipeline which includes the infrastructure needed for pre-clinical and clinical trials in trauma and critical care. Funding from federal sources, industry, philanthropy and venture capital will be discussed. Panelists will include representation from the NIH, BARDA, DOD, industry stakeholders and a venture capital firm.

4:00 pm - 5:00 pm
Session 2 | Challenges in Product Development, Cell Production and Processing

Discussion will focus upon the translational barriers and challenges that exist in cell product production, development and processing. Panelists will include representation from the private industry, blood banks and academic centers involved in this space.

  • Moderator: Kenneth Bertram MD, PhD

    Professor of Regenerative Medicine, COL US Army (Ret)
    Wakeforest University

  • Becky Cap

    BioBridge Global

  • David McKenna MD

    American Red Cross Chair in Transfusion Medicine
    Director of the Division of Transfusion Medicine

  • Fabio Triolo PhD

    UT Houston

  • Jon Rowley PhD

    Chief Executive & Technology Officer, RoosterBio, Inc.

  • Julie Allickson PhD

    Director, Regenerative Medicine Clinical Center
    Wake Forest University School of Medicine
    Winston-Salem, NC

  • Robert Mays PhD

    Athersys- Vice President, Regenerative Medicine
    Head of Neurosciences, Athersys, Inc. Cleveland, OH

5:00 pm - 6:00 pm
Reception – Aragon Terrace
6:00 pm - 6:30 pm
2019 Keynote | The Power of Yes
  • Dr. Geoffrey Ling MD, PhD COL US AirForce (Ret)

    Chief Executive Officer at SunQ, LLC
    Ex Director of the Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office

6:30 pm - 9:00 pm
Dinner – Aragon Lawn

Thursday, December 12 | Transfusion Medicine in Trauma and Critical Care

The goal of this session is to discuss and understand pertinent issues in transfusion medicine and novel blood products related to the bleeding and acutely injured trauma patient. Topics of discussion will focus around novel blood products and adjuncts to resuscitation in bleeding patients.

7:00 am - 8:00 am
Breakfast | Aragon Lawn

Visit Exhibits

7:00 am - 5:00 pm
Registration Area Open – Aragon Pre-Function North

Badge and Materials Pickup

8:00 am - 8:05 am
Welcome & Introduction
  • Shibani Pati MD, PhD

    CTTACC Conference Chair
    Associate Professor and Scientific Director of Cellular Therapies UCSF

Session 1 | Whole Blood – The First Cell Therapy in Trauma

8:05 am - 8:20 am
Civilian Whole Blood Use: The Portland, OR Experience
  • Martin Schreiber MD

    CTTACC Conference Co-Chair
    COL US ARMY Professor of Surgery & Chief of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Sciences University (OHSU)

8:20 am - 8:35 am
Military Whole Blood Use
  • COL Stacey Shackleford MD

    Chief, Joint Trauma System Defense Center of Excellence for Trauma, US Army Institute of Surgical Research—Houston, TX

8:35 am - 8:50 am
Civilian Whole Blood Use: The Pittsburgh, PA Experience
  • Jason Sperry MD, MPH

    Professor of Surgery and Critical Care
    Director of Acute Care Surgery Fellowship
    University of Pittsburgh, Pittsburgh,PA

8:50 am - 9:05 am
Question & Answer Panel | Session 1

Session 2 | Novel Resuscitation Adjuncts and Blood Products in Trauma

9:05 am - 9:20 am
Resuscitation Adjuncts in Trauma
  • Hasan Alam MD

    Professor of Surgery University of Michigan

9:20 am - 9:35 am
COMBAT Trial Pre-Hospital Plasma
  • Ernest Moore MD

    Professor of Surgery University of Colorado, Denver

9:35 am - 9:50 am
Tranxanemic Acid as a Resuscitative Adjunct for Treatment of TBI
  • Martin Schreiber MD

    CTTACC Conference Co-Chair
    COL US ARMY Professor of Surgery & Chief of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Sciences University (OHSU)

9:50 am - 10:05 am
Pre-Hospital Cryoprecipitate and Factor Concentrate Use in Trauma and Hemorrhage
  • Karim Brohi MD

    Professor of Surgery Queen Mary Hospital, UK

10:05 am - 10:20 am
Blood Banks Providing Novel and Alternative Blood Products
  • Beth Shaz MD

    President Elect AABB
    Chief Medical and Scientific Officer
    Senior Vice President at New York Blood Center

10:20 am - 10:35 am
Question & Answer Panel | Session 2

Discussion Panel on Challenges in the Development, Study and Implementation of Pre-hospital Interventions

  • Moderator: John Holcomb MD

    Vice Chair and Professor of Surgery at UTHSC-Houston, TX
    Director, Center for Translational Injury Research, UTHSC

  • Beth Shaz MD

    President Elect AABB
    Chief Medical and Scientific Officer
    Senior Vice President at New York Blood Center

  • Ernest Moore MD

    Professor of Surgery University of Colorado, Denver

  • Jason Sperry MD, MPH

    Professor of Surgery and Critical Care
    Director of Acute Care Surgery Fellowship
    University of Pittsburgh, Pittsburgh,PA

  • Karim Brohi MD

    Professor of Surgery Queen Mary Hospital, UK

  • Martin Schreiber MD

    CTTACC Conference Co-Chair
    COL US ARMY Professor of Surgery & Chief of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Sciences University (OHSU)

10:35 am - 11:05 am
Coffee Break – Aragon Pre-Function North

Visit Exhibits

Session 3 | Dried Plasma, Artificial RBCs and Pathogen Reduction of Blood

11:05 am - 11:20 am
Lyophilized Plasma and Plasma in Trauma Associated Sepsis
  • Rosemary Kozar MD, PhD

    U of MD-Professor of Surgery, Vice Chair of Research Univ. of Maryland Baltimore, MD

11:20 am - 11:35 am
Pathogen Reduction in Transfusion Safety of Novel Blood Products
  • Larry Corash MD

    Senior VP and CMO Cerus Inc. Concord, CA

11:35 am - 11:50 am
Novel Bio-Inspired Artificial RBC (Erythromer): Early Pre-clinical Results
  • Allan Doctor MD

    Professor of Pediatric Critical Care Medicine
    Washington University St. Louis

11:50 am - 12:05 pm
Question & Answer Panel | Session 3
12:05 pm - 1:05 pm
Lunch

Visit Exhibits

Session 4 | Novel Platelet and Platelet Derived Products

1:05 pm - 1:20 pm
Freeze Dried Platelets in Trauma Related Applications- Pre-clinical to Clinical Translation
  • Mike Fitzpatrick PhD

    COL, USA, (Ret.); President & Director of Research and Development, Cellphire

1:20 pm - 1:35 pm
Platelet Studies
  • Karim Brohi MD

    Professor of Surgery Queen Mary Hospital, UK

1:35 pm - 1:50 am
Cold Stored Platelets in Trauma – The Optimal Product for Military and Civilian Use
  • Andre Cap MD, PhD

    COL US Army Director Blood Research Program
    US Army Institute for Surgical Research

1:50 pm - 2:05 pm
Platelet Biology and Cytoskeletal Mechanics
  • Owen McCarty PhD

    Professor and Chair of Department of Biomedical Engineering, Professor of Department of Cell & Development Biology

2:05 pm - 2:20 pm
Regulating the Endotheliopathy of Trauma with 4C Platelets & Platelet Extracellular Vesicles
  • Shibani Pati MD, PhD

    CTTACC Conference Chair
    Associate Professor and Scientific Director of Cellular Therapies UCSF

2:20 pm - 2:35 pm
Freeze Dried Platelets in Treating Traumatic Brain Injury
2:35 pm - 2:50 pm
Question & Answer Panel | Session 4
2:50 pm - 3:20 pm
Coffee Break – Aragon Pre-Function North

Visit Exhibits

Session 5 | Product Development and Regulatory Approval of Novel Blood Products

3:20 pm - 3:35 pm
Priorities for Military Medicine and Research
  • COL Michael Davis

    Director of Combat Casualty Care Research, Ft. Detrick Maryland

3:35 pm - 4:35 pm
Introduction to Novel Product Development in Transfusion Medicine-Novel Blood Products
  • Moderator: Richard Gonzales COL US Army (Ret)

    Richblo2d Biologics Consulting Services LLC
    San Antonio, TX

  • Moderator: Kenneth Bertram MD, PhD

    Professor of Regenerative Medicine, COL US Army (Ret)
    Wakeforest University

  • Larry Corash MD

    Senior VP and CMO Cerus Inc. Concord, CA

  • Mark Popovsky MD

    Velico Medical, Inc

  • Mike Fitzpatrick PhD

    COL, USA, (Ret.); President & Director of Research and Development, Cellphire

  • Peter Marks MD, PhD

    Director of the Center for Biologics Evaluation and Research, FDA

5:00 pm - 6:00 pm
Reception – Buena Vista Terrace
6:00 pm - 9:00 pm
Dinner – Promanade

Friday, December 13 | Cellular Therapies in Trauma and Critical Care Medicine

The goal of this session is to discuss and learn about the state of the science of cellular therapies in trauma and critical care. Pre-clinical and clinical studies will be presented in traumatic brain injury (TBI), Spinal Cord Injury (SCI), acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), wound healing and tissue and bone regeneration.

7:00 am - 8:00 am
Breakfast – Aragon Lawn

Visit Exhibits

7:00 am - 1:00 pm
Registration Area Open – Aragon Pre-Function North

Badge and Materials Pickup

8:00 am - 8:30 am
Plenary Talk | A Success Story in Cellular Therapies Allogeneic CAR-T Cell Therapy
  • David Chang MD, PhD

    CEO and President Allogene Therapeutics Inc.
    South San Francisco, CA

Session 1 | Cellular Therapies in Critical Care Medicine

8:30 am - 8:50 am
IPSC derived Cardiomyocytes in Cardiac Disease and Repair
  • Joseph C. Wu MD, PhD

    Director, Stanford Cardiovascular Institute Simon H. Stertzer, MD
    Professor of Medicine & Radiology Stanford University School of Medicine

8:50 am - 9:10 am
Innate Immunity in Injury
  • Clifford Lowell MD, PhD

    Professor and Chair Laboratory Medicine, UCSF San Francisco, CA

9:10 am - 9:30 am
Cellular Therapies in ARDS – Pre-clinial to Clinical Trials
  • Michael Matthay MD

    Professor of Pulmonary Critical Care Medicine and Assoc.
    Director of ICU-UCSF San Francisco, CA

9:30 am - 9:50 am
Multipotent Adult Progenitor Cells in ARDS
  • Robert Mays PhD

    Athersys- Vice President, Regenerative Medicine
    Head of Neurosciences, Athersys, Inc. Cleveland, OH

9:50 am - 10:05 am
Question & Answer Panel | Session 1
10:05 am - 10:35 am
Coffee Break – Aragon Pre-Function North

Visit Exhibits

Session 2 | Cellular Therapies in Bone, Organ and Tissue Repair

10:35 am - 10:55 am
Cellular Therapies in Wound Healing and Tissue Injury
  • Jan Nolta PhD

    Professor and Stem Cell Program Director UC Davis Medical Center UCD, Sacramento, CA
    Editor of the Journal- Stem Cells

10:55 am - 11:15 am
Organ Regeneration in Trauma
  • Anthony Atala MD

    Director Regenerative Medicine, Wakeforest University NC

11:15 am - 11:35 am
Bone Orthopedic Healing with Stem Cells TBN
11:35 am - 11:55 am
French Military Clinical Experience with MSCs in Thermal and Radiation Burn Injury
  • Christophe Martinaud MD

    Professor of Transfusion Medicine and Cell Therapy
    French Military Blood Institute Clamart Cedex, France

11:55 am - 12:15 pm
Platelet Biogenesis & IPSC-derived Platelets
  • Jonathan Thon PhD

    CEO at Platelet BioGenesis Boston, MA

12:15 pm - 12:30 pm
Question & Answer Panel | Session 2
12:30 pm - 1:30 pm
Lunch

Visit Exhibits

Session 3 | Cellular Therapies in Neurotrauma

1:30 pm - 1:50 pm
Human Stem Cell Grafts in Spinal Cord Injury (SCI) and Repair
  • Ephron Rosenzweig PhD

    Assistant Professor of Neurosciences, Center for Neural Repair UCSD, San Diego, CA

1:50 pm - 2:10 pm
Human Clinical Trial of Neural Progenitor Cells in SCI
2:10 pm - 2:30 pm
Adult and Pediatric Clinical Trials of HSCs and MAPCs in Traumatic Brain Injury (TBI)
  • Charles Cox MD

    Professor of Pediatric Surgery- University of Texas Houston
    Children’s Fund Distinguished Professor Center for Stem Cell & Regenerative Medicine

2:30 pm - 2:45 pm
Question & Answer Panel | Session 3

Session 4 | New Technologies, Regulatory Issues and Challenges in the Field

2:45 pm - 3:05 pm
FDA Perspective: Cellular Therapies
  • Peter Marks MD, PhD

    Director of the Center for Biologics Evaluation and Research, FDA

3:05 pm - 3:25 pm
Challenges of Clinical Cell Product Production in an Academic Center
  • Jonathan Esensten MD, PhD

    Assistant Professor, Director of Cell Therapy Facility and Blood bank at SFGH UCSF

3:25 pm - 3:40 pm
Session 4 Question & Answer Panel | Concluding Remarks

Presented by the University of California San Francisco Department of Laboratory Medicine

Questions? Email us at info@cttacc.org or call 303-238-0685